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Functional stapled fragments of human preptin of minimised length
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SYSNO ASEP 0556184 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Functional stapled fragments of human preptin of minimised length Author(s) Lubos, Marta (UOCHB-X) ORCID
Mrázková, Lucie (UOCHB-X)
Gwozdiaková, Petra (UOCHB-X)
Pícha, Jan (UOCHB-X) RID, ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Jiráček, Jiří (UOCHB-X) RID, ORCID
Kaminský, Jakub (UOCHB-X) RID, ORCID
Žáková, Lenka (UOCHB-X) RID, ORCIDSource Title Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 20, č. 12 (2022), s. 2446-2454Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords alpha-helical peptides ; secondary structure ; force field OECD category Biochemistry and molecular biology R&D Projects GA19-14069S GA ČR - Czech Science Foundation (CSF) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LTAUSA18085 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure e-INFRA CZ - 90140 - CESNET, zájmové sdružení právnických osob Method of publishing Limited access Institutional support UOCHB-X - RVO:61388963 UT WOS 000765387300001 EID SCOPUS 85127142797 DOI 10.1039/d1ob02193a Annotation Preptin is peptide derived from the of insulin-like growth factor 2 ( pro-IGF2). We describe the synthesis, structures, and biological activities of scyclic analogues of human preptin with different covalent intramolecular bridges. We monitored the secondary structures of the stapled peptides using circular dichroism. The biological effect of the structural changes was determined afterwards by the ability of peptides to stimulate the release of intracellular calcium ions. Our findings could open up new ways to design new preptin analogues, which may have potential as drugs for the treatment of diabetes and osteoporosis. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2023 Electronic address https://doi.org/10.1039/D1OB02193A
Number of the records: 1