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Biomarkers of Oxidative Stress and Inflammation in Researches Exposed to Nanoparticles by Inhalation During the Handling of Nanocomposites.
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SYSNO ASEP 0547257 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Biomarkers of Oxidative Stress and Inflammation in Researches Exposed to Nanoparticles by Inhalation During the Handling of Nanocomposites. Author(s) Pelclová, D. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Schwarz, Jaroslav (UCHP-M) RID, ORCID, SAI
Komarc, M. (CZ)
Vlčková, Š. (CZ)
Fenclová, Z. (CZ)
Lischková, L. (CZ)
Dvořáčková, Š. (CZ)
Rössnerová, Andrea (UEM-P) RID
Rössner ml., Pavel (UEM-P) RID, ORCIDSource Title NANOCON 2018 - Conference Proceedings. - Ostrava : Tanger Ltd., 2019 - ISBN 978-80-87294-89-5 Pages s. 531-536 Number of pages 6 s. Publication form Print - P Action Anniversary International Conference on Nanomaterials - Research and Application /10./ Event date 17.10.2018 - 19.10.2018 VEvent location Brno Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords Nanocomposites ; exhaled breath condensate ; oxidative stress Subject RIV DN - Health Impact of the Environment Quality OECD category Public and environmental health Subject RIV - cooperation Institute of Experimental Medicine - Health Impact of the Environment Quality Institutional support UCHP-M - RVO:67985858 ; UEM-P - RVO:68378041 UT WOS 000513131900092 EID SCOPUS 85062955844 Annotation At present, little is known about the health effects in the workers processing nanocomposites. In our study, 20 researchers (41.8 +/- 11.4 y/o), handling nanocomposites for 17.8 +/- 10.0 years were examined pre-shift and post-shift, together with 21 controls (42.7 +/- 11.5 y/o). Biomarkers of oxidative stress derived from lipids, nucleic acids, proteins and markers of inflammation were analyzed in the exhaled breath condensate (EBC). Aerosol exposure was monitored during three nanoparticle generation operations: smelting, welding and nanocomposite machining. Mass concentrations during these operations ranged from 0.120 to 1.840 mg/m(3), and median particle number concentrations from 4.8x10(4) to 5.4x10(5) particles/cm(3). Nanoparticles accounted for 40 to 95 % of particles, with Fe and Mn prevailing. Significant elevations were already seen in most oxidative stress markers and in several inflammation markers in the pre-shift samples relative to the controls. Significant associations were found between working in nanocomposite synthesis and the majority of EBC biomarkers. Chronic bronchitis was more frequent in researchers. A minor, but significant post-shift decrease of lung function parameters was found. We conclude that workers in nanocomposite synthesis may be at risk of developing airway disorders with time. From all the markers analyzed in EBC, the following markers were most robust and could be recommended for preventive examinations: 8-hydroxy-2-deoxyguanosine (8-OHdG) and 5-hydroxymethyl uracil (5-OHMeU) from nucleic acids, o-tyrosine (o-Tyr) and 3-nitrotyrosine (3-NOTyr) from proteins, and malondialdehyde and aldehydes C6-C13 from lipids. Among the markers of inflammation, tumor necrosis factor (TNF) and leukotriene B4 appeared to be the most useful. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2022
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