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Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application
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SYSNO ASEP 0545534 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application Author(s) Koper, F. (PL)
Świergosz, T. (PL)
Zaba, A. (PL)
Flis, A. (PL)
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Pamula, E. (PL)
Bogdal, D. (PL)
Kasprzyk, W. P. (PL)Source Title Journal of Materials Chemistry B - ISSN 2050-750X
Roč. 9, č. 32 (2021), s. 6425-6440Number of pages 16 s. Language eng - English Country GB - United Kingdom Keywords Poly(alkylene citrate) (PAC) biomaterials ; biological and mechanical properties ; biocompatibility ; tissue engineering Subject RIV EI - Biotechnology ; Bionics OECD category Biomaterials (as related to medical implants, devices, sensors) R&D Projects GA21-06065S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000678728400001 EID SCOPUS 85113201409 DOI 10.1039/D1TB01078F Annotation Herein, a renewed prominence towards the synthesis of poly(alkylene citrate) (PAC) biomaterials and their detailed chemical, structural and mechanical characterization has been reported. Based on the modifications to the PAC synthesis protocol introduced in this study, the fabrication process was significantly streamlined, the reaction yields were increased, and the homogeneity of the final materials was found to be substantially improved. Comprehensive nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) studies of the fabricated prepolymers shed light on the mechanism of the PAC cross-linking process and supported the design of materials with enhanced biocompatibility. Therefore, the initial molar ratio of the reagents involved in the synthesis of PAC materials was found to be pivotal to both the biological and mechanical properties of the final products. Moreover, cell viability and proliferation assays revealed enhanced biocompatibility of the materials formulated with a molar ratio of diol over citric acid (3 : 2 mol/mol) in comparison to the most commonly described 1 : 1 analogue without affecting the possibility of further functionalization. Furthermore, this work creates a new paradigm for prospective studies on the properties of modified PAC materials and their application in medicine and tissue engineering. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://doi.org/10.1039/D1TB01078F
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