Evolution of Diverse Strategies for Promoter Regulation

0544549 - BFÚ 2022 RIV NL eng J - Journal Article
Brázda, Václav - Bartas, M. - Bowater, R. P.
Evolution of Diverse Strategies for Promoter Regulation.
Trends in Genetics. Roč. 37, č. 8 (2021), s. 730-744. ISSN 0168-9525. E-ISSN 1362-4555
R&D Projects: GA ČR(CZ) GA18-15548S
Institutional support: RVO:68081707
Keywords : inverted repeat sequences * g-quadruplex structures * dna g-quadruplex * non-b dna * gene-regulation * transposable elements
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 11.821, year: 2021
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0168952521000846

DNA is fundamentally important for all cellular organisms due to its role as a store of hereditary genetic information. The precise and accurate regulation of gene transcription depends primarily on promoters, which vary significantly within and between genomes. Some promoters are rich in specific types of bases, while others have more varied, complex sequence characteristics. However, it is not only base sequence but also epigenetic modifications and altered DNA structure that regulate promoter activity. Significantly, many promoters across all organisms contain sequences that can form intrastrand hairpins (cruciforms) or four-stranded structures (G-quadruplex or i-motif). In this review we integrate recent studies on promoter regulation that highlight the importance of DNA structure in the evolutionary adaptation of promoter sequences.
Permanent Link: http://hdl.handle.net/11104/0321397