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Catalase and Ascorbate Peroxidase in Euglenozoan Protists
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SYSNO ASEP 0540625 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Catalase and Ascorbate Peroxidase in Euglenozoan Protists Author(s) Škodová-Sveráková, Ingrid (BC-A) RID
Záhonová, Kristýna (BC-A) ORCID
Bučková, B. (SK)
Füssy, Z. (CZ)
Yurchenko, V. (CZ)
Lukeš, Julius (BC-A) RID, ORCIDNumber of authors 6 Article number 317 Source Title Pathogens. - : MDPI
Roč. 9, č. 4 (2020)Number of pages 16 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords hydrogen-peroxide ; glutathione-reductase ; oxidative stress ; leishmania-major ; tobacco plants ; gene family ; metabolism ; trypanothione ; prediction ; antioxidants ; Euglenozoa ; ascorbate peroxidase ; catalase ; enzymatic activity ; phylogeny Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects LL1601 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA18-15962S GA ČR - Czech Science Foundation (CSF) GA20-07186S GA ČR - Czech Science Foundation (CSF) EF16_019/0000759 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 000534051600058 EID SCOPUS 85084967483 DOI 10.3390/pathogens9040317 Annotation In this work, we studied the biochemical properties and evolutionary histories of catalase (CAT) and ascorbate peroxidase (APX), two central enzymes of reactive oxygen species detoxification, across the highly diverse clade Eugenozoa. This clade encompasses free-living phototrophic and heterotrophic flagellates, as well as obligate parasites of insects, vertebrates, and plants. We present evidence of several independent acquisitions of CAT by horizontal gene transfers and evolutionary novelties associated with the APX presence. We posit that Euglenozoa recruit these detoxifying enzymes for specific molecular tasks, such as photosynthesis in euglenids and membrane-bound peroxidase activity in kinetoplastids and some diplonemids. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2021 Electronic address https://www.mdpi.com/2076-0817/9/4/317
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