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Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications
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SYSNO ASEP 0540031 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications Author(s) Frtus, A. (CZ)
Smolková, B. (CZ)
Uzhytchak, M. (CZ)
Lunova, M. (CZ)
Jirsa, M. (CZ)
Kubinová, Šárka (UEM-P) RID, ORCID
Dejneka, A. (CZ)
Lunov, O. (CZ)Source Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 328, dec. (2020), s. 59-77Number of pages 19 s. Language eng - English Country NL - Netherlands Keywords iron oxide nanoparticles ; endocytosis ; magnetic resonance imaging Subject RIV BO - Biophysics OECD category Biophysics Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000600791600005 EID SCOPUS 85089899628 DOI 10.1016/j.jconrel.2020.08.036 Annotation Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification. We describe mechanisms of IONPs-induced toxicity. Ultimately, we demonstrate that knowledge of cellular mechanisms of IONPs action helped to overcome certain translation problems in nanomedicine - we explore potential causes and challenges associated with poor clinical performance of IONPs and propose outlook of how to overcome problems in the field. Our critical analysis implies that a clear understanding of molecular mechanisms of IONPs-cell interactions will provide a basement to increase the likelihood for clinical success of IONPs. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/abs/pii/S0168365920304776?via%3Dihub
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