Modulation of differentiation of embryonic stem cells by polypyrrole: the impact on neurogenesis

0537040 - ÚMCH 2022 RIV CH eng J - Journal Article
Skopalová, K. - Radaszkiewicz, K. A. - Kašpárková, V. - Stejskal, Jaroslav - Bober, Patrycja - Junkar, I. - Mozetič, M. - Capáková, Z. - Lehocký, M. - Kašparová, M. - Pacherník, J. - Humpolíček, P.
Modulation of differentiation of embryonic stem cells by polypyrrole: the impact on neurogenesis.
International Journal of Molecular Sciences. Roč. 22, č. 2 (2021), č. článku 501. E-ISSN 1422-0067
Institutional support: RVO:61389013
Keywords : conducting polymer * polypyrrole * biocompatibility
OECD category: Polymer science
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/2/501

The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
Permanent Link: http://hdl.handle.net/11104/0315711