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Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage
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SYSNO ASEP 0532829 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage Author(s) Montesinos, J. C. (AT)
Abuzeineh, A. (BE)
Kopf, A. (AT)
Juanes-Garcia, A. (AT)
Ötvös, K. (AT)
Petrášek, Jan (UEB-Q) RID, ORCID
Sixt, M. (AT)
Benková, E. (AT)Number of authors 8 Article number e104238 Source Title EMBO Journal. - : Wiley - ISSN 0261-4189
Roč. 39, č. 17 (2020)Number of pages 22 s. Language eng - English Country GB - United Kingdom Keywords cell differentiation ; cytokinin ; cytoskeleton ; microtubules ; microtubules dynamics Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemical research methods R&D Projects EF16_019/0000738 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000548311800001 EID SCOPUS 85087860829 DOI 10.15252/embj.2019104238 Annotation Cell production and differentiation for the acquisition of specific functions are key features of living systems. The dynamic network of cellular microtubules provides the necessary platform to accommodate processes associated with the transition of cells through the individual phases of cytogenesis. Here, we show that the plant hormone cytokinin fine-tunes the activity of the microtubular cytoskeleton during cell differentiation and counteracts microtubular rearrangements driven by the hormone auxin. The endogenous upward gradient of cytokinin activity along the longitudinal growth axis in Arabidopsis thaliana roots correlates with robust rearrangements of the microtubule cytoskeleton in epidermal cells progressing from the proliferative to the differentiation stage. Controlled increases in cytokinin activity result in premature re-organization of the microtubule network from transversal to an oblique disposition in cells prior to their differentiation, whereas attenuated hormone perception delays cytoskeleton conversion into a configuration typical for differentiated cells. Intriguingly, cytokinin can interfere with microtubules also in animal cells, such as leukocytes, suggesting that a cytokinin-sensitive control pathway for the microtubular cytoskeleton may be at least partially conserved between plant and animal cells. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2021 Electronic address http://doi.org/10.15252/embj.2019104238
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