The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

0531162 - MBÚ 2021 RIV US eng J - Journal Article
Schafer, H. - Beckert, B. - Frese, Ch.K. - Steinchen, W. - Nuss, A.M. - Beckstette, M. - Hantke, I. - Driller, K. - Sudzinová, Petra - Krásný, Libor - Kaever, V. - Dersch, P. - Bange, G. - Wilson, D.N. - Turgay, K.
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
PLoS Genetics. Roč. 16, č. 3 (2020), č. článku e1008275. ISSN 1553-7404. E-ISSN 1553-7404
R&D Projects: GA ČR(CZ) GA19-12956S; GA MŠMT(CZ) LM2015055
Institutional support: RVO:61388971
Keywords : nutritional stress activation * protein-quality control * stringent response
OECD category: Microbiology
Impact factor: 5.917, year: 2020
Method of publishing: Open access
https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275

We observed that the second messenger (p)ppGpp, known to be synthesized by the ribosome-associated Rel synthetase upon nutrient starvation during the stringent response, is also intricately involved in the stress response of B. subtilis cells and can act as a pleiotropic regulator during the adaptation to heat stress. (p)ppGpp can slow down and modulate translation and is, together with the transcriptional stress regulator Spx, partially involved in the transcriptional down-regulation of the translation machinery. The stress-induced elevation of cellular (p)ppGpp levels confers increased stress tolerance and facilitates an improved protein homeostasis by modulating translation and reducing the load on the protein quality control system.
Permanent Link: http://hdl.handle.net/11104/0309884