Antibacterial silver-conjugated magnetic nanoparticles: design, synthesis and bactericidal effect

Shatan, Anastasiia-Bohdana; Venclíková, Kristýna; Zasońska, Beata Anna; Patsula, Vitalii; Pop-Georgievski, Ognen; Petrovský, Eduard; Horák, Daniel

doi:https://dx.doi.org/10.1007/s11095-019-2680-x

Number of the records: 1

Antibacterial silver-conjugated magnetic nanoparticles: design, synthesis and bactericidal effect

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SYSNO ASEP	0507831
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Antibacterial silver-conjugated magnetic nanoparticles: design, synthesis and bactericidal effect
Author(s)	Shatan, Anastasiia-Bohdana (UMCH-V)_{RID, ORCID} Venclíková, Kristýna (UMCH-V)_RID Zasońska, Beata Anna (UMCH-V)_{RID, ORCID} Patsula, Vitalii (UMCH-V)_{RID, ORCID} Pop-Georgievski, Ognen (UMCH-V)_{RID, ORCID} Petrovský, Eduard (GFU-E)_{ORCID, RID} Horák, Daniel (UMCH-V)_{RID, ORCID}
Article number	147
Source Title	Pharmaceutical Research. - : Springer - ISSN 0724-8741 Roč. 36, č. 10 (2019), s. 1-12
Number of pages	12 s.
Language	eng - English
Country	US - United States
Keywords	antibacterial activity ; magnetic nanoparticles ; silica shell
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Geophysical Institute - Earth Magnetism, Geodesy, Geography
R&D Projects	GA17-04918S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; GFU-E - RVO:67985530
UT WOS	000480804200001
EID SCOPUS	85070703125
DOI	10.1007/s11095-019-2680-x
Annotation	The aim was to design and thoroughly characterize monodisperse Fe3O4@SiO2-Ag nanoparticles with strong antibacterial properties, which makes them a candidate for targeting bacterial infections.The monodisperse Fe3O4 nanoparticles were prepared by oleic acid-stabilized thermal decomposition of Fe(III) oleate. The particles were coated with silica shell using a water-in-oil reverse microemulsion, involving hydrolysis and condensation of tetramethyl orthosilicate. Resulting Fe3O4@SiO2 particles were modified by (3-mercaptopropyl)trimethoxysilane to introduce 1.1 mmol SH/g. Finally, the Fe3O4@SiO2-SH nanoparticles were decorated with silver nanoclusters formed by reduction of silver nitrate with NaBH4. The particles were analyzed by FTIR, X-ray photoelectron and atomic absorption spectroscopy, dynamic light scattering and vibrating sample magnetometry. The antibacterial activity of the Fe3O4@SiO2 and Fe3O4@SiO2-Ag nanoparticles was tested against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria cultivated on Luria agar plates or in Luria broth. The superparamagnetic Fe3O4@SiO2-Ag nanoparticles (21 nm in diameter. Saturation magnetization 26 A∙m2/kg) were successfully obtained and characterized. Inhibitory and toxic effects against bacteria were documented by incubation of the Fe3O4@SiO2-Ag nanoparticles with Staphylococcus aureus and Escherichia coli. The combination of magnetic properties together with bactericidal effects is suitable for the disinfection of medical instruments, water purification, food packaging, etc.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2020
Electronic address	https://link.springer.com/article/10.1007%2Fs11095-019-2680-x

Number of the records: 1