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No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder
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SYSNO ASEP 0504884 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder Author(s) Janíková, Martina (FGU-C) ORCID
Brožka, Hana (FGU-C) ORCID, SAI, RID
Radostová, Dominika (FGU-C) ORCID, RID, SAI
Svoboda, Jan (FGU-C) RID, ORCID
Stuchlík, Aleš (FGU-C) RID, ORCIDSource Title Physiology and Behavior. - : Elsevier - ISSN 0031-9384
Roč. 204, May 15 (2019), s. 241-247Number of pages 7 s. Language eng - English Country US - United States Keywords Quinpirole ; Memantine ; Riluzole ; obsessive-compulsive disorder ; active allothetic place avoidance task Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GA17-04047S GA ČR - Czech Science Foundation (CSF) NV15-34524A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000467509100032 EID SCOPUS 85062488694 DOI 10.1016/j.physbeh.2019.01.013 Annotation Rationale:Chronic quinpirole (QNP) sensitization is an established animal model relevant to obsessive-compulsive disorder (OCD) that has been previously shown to induce several OCD-like behavioral patterns, such as compulsive-like checking and increased locomotion.Objectives:In current study we explored the effect of antiglutamatergic drugs, memantine and riluzole, on cognitive and behavioral performance of QNP sensitized rats.Methods:During habituation phase, the rats (N = 56) were injected with QNP (0.25 mg/kg) or saline solution (every other day up to 10 injections) and placed into rotating arena without foot shocks for 50-min exploration. Active place avoidance task in rotating arena with unmarked to-be-avoided shock sector was used during acquisition phase. Rats were injected with memantine (1 mg/kg or 5 mg/kg), riluzole (1 mg/kg or 5 mg/kg) or saline solution 30 min before the trial and with QNP (0.25 mg/kg) or saline right before they were placed inside the rotating arena with 60° unmarked shock sector. Locomotion and number of entrances into the shock sector were recorded.Results:QNP sensitization led to a robust deficit in place learning. However, neither memantine nor riluzole did reverse or alleviate the deficit induced by QNP. Contrarily, memantine significantly aggravated QNP induced deficit.Conclusions:The exacerbation of cognitive deficit following antiglutamatergic agents could be mediated by decreased glutamate concentration in nucleus accumbens and decreased hippocampal activation in the QNP sensitization model. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2020 Electronic address https://doi.org/10.1016/j.physbeh.2019.01.013
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