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Synergic effect of CNT and mechanical loading for acceleration of cell differentiation
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SYSNO ASEP 0503495 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synergic effect of CNT and mechanical loading for acceleration of cell differentiation Author(s) Mázl Chánová, Eliška (UMCH-V) RID
Kredatusová, Jana (UMCH-V) RID
Knotek, P. (CZ)
Kubies, Dana (UMCH-V) RID, ORCID
Yang, Y. (GB)Source Title International Journal of Polymeric Materials and Polymeric Biomaterials. - : Taylor & Francis - ISSN 0091-4037
Roč. 68, 1-3 (2019), s. 83-89Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords CNT ; RGDS ; cell differentiation Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects EF17_050/0008473 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000467974500010 EID SCOPUS 85058995231 DOI 10.1080/00914037.2018.1525726 Annotation Herein, we investigate the synergic effect of carbon nanotubes (CNT) in conjunction with mechanical load applied in early stage of cell cultivation to accelerate differentiation in bone cells. To improve their biofunctionality, CNT were functionalized with carboxyl groups and RGD peptide. The effect of CNT functionalization on cell proliferation and formation of cell aggregates with hastened production of calcium deposits was studied with and MG63 cell lines in static and dynamic conditions. Combination of CNT with mechanical load promoted significantly higher osteogenic marker expression and formation of calcium deposits in comparison to the control, particularly in case of MSC. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2020 Electronic address https://www.tandfonline.com/doi/pdf/10.1080/00914037.2018.1525726?needAccess=true
Number of the records: 1