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Membrane Lipid Nanodomains
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SYSNO ASEP 0498437 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Membrane Lipid Nanodomains Author(s) Cebecauer, Marek (UFCH-W) RID, ORCID, SAI
Amaro, Mariana (UFCH-W) RID, ORCID
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Šachl, Radek (UFCH-W) RID, ORCID
Cwiklik, Lukasz (UFCH-W) RID, ORCID
Hof, Martin (UFCH-W) RID, ORCIDSource Title Chemical Reviews. - : American Chemical Society - ISSN 0009-2665
Roč. 118, č. 23 (2018), s. 11259-11297Number of pages 39 s. Language eng - English Country US - United States Keywords membranes ; nanomaterials ; lipids Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GA17-03160S GA ČR - Czech Science Foundation (CSF) Institutional support UFCH-W - RVO:61388955 UT WOS 000453488700001 EID SCOPUS 85056091029 DOI 10.1021/acs.chemrev.8b00322 Annotation Lipid membranes can spontaneously organize their components into domains of different sizes and properties. The organization of membrane lipids into nanodomains might potentially play a role in vital functions of cells and organisms. Model membranes represent attractive systems to study lipid nanodomains, which cannot be directly addressed in living cells with the currently available methods. This review summarizes the knowledge on lipid nanodomains in model membranes and exposes how their specific character contrasts with large-scale phase separation. The overview on lipid nanodomains in membranes composed of diverse lipids (e.g., zwitterionic and anionic glycerophospholipids, ceramides, glycosphingolipids) and cholesterol aims to evidence the impact of chemical, electrostatic, and geometric properties of lipids on nanodomain formation. Furthermore, the effects of curvature, asymmetry, and ions on membrane nanodomains are shown to be highly relevant aspects that may also modulate lipid nanodomains in cellular membranes. Potential mechanisms responsible for the formation and dynamics of nanodomains are discussed with support from available theories and computational studies. A brief description of current fluorescence techniques and analytical tools that enabled progress in lipid nanodomain studies is also included. Further directions are proposed to successfully extend this research to cells. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2019
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