Regulation of microtubule nucleation mediated by gamma-tubulin complexes

0487077 - ÚMG 2018 RIV AT eng J - Journal Article
Sulimenko, Vadym - Hájková, Zuzana - Klebanovych, Anastasiya - Dráber, Pavel
Regulation of microtubule nucleation mediated by gamma-tubulin complexes.
Protoplasma. Roč. 254, č. 3 (2017), s. 1187-1199. ISSN 0033-183X. E-ISSN 1615-6102
R&D Projects: GA MŠMT(CZ) LD13015
Institutional support: RVO:68378050
Keywords : mitotic spindle formation * ring complex * fission yeast * organizing centers * protein complex * golgi-complex * cell-cycle * pole body * augmin * centrosome * Centrosomes * Microtubule nucleation * Microtubule-organizing centers * Non-centrosomal nucleation sites * Spindle pole bodies * gamma-Tubulin complexes
OECD category: Cell biology
Impact factor: 2.457, year: 2017

The microtubule cytoskeleton is critically important for spatio-temporal organization of eukaryotic cells. The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma-tubulin that assembles into multisubunit complexes of various sizes. gamma-Tubulin ring complexes (TuRCs) are efficient microtubule nucleators and are associated with large number of targeting, activating and modulating proteins. gamma-Tubulin-dependent nucleation of microtubules occurs both from canonical MTOCs, such as spindle pole bodies and centrosomes, and additional sites such as Golgi apparatus, nuclear envelope, plasma membrane-associated sites, chromatin and surface of pre-existing microtubules. Despite many advances in structure of gamma-tubulin complexes and characterization of gamma TuRC interacting factors, regulatory mechanisms of microtubule nucleation are not fully understood. Here, we review recent work on the factors and regulatory mechanisms that are involved in centrosomal and non-centrosomal microtubule nucleation.
Permanent Link: http://hdl.handle.net/11104/0281758