Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review

0485737 - BFÚ 2018 RIV CH eng J - Journal Article
Hofer, Michal - Hoferová, Zuzana - Depeš, Daniel - Falk, Martin
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.
Molecules. Roč. 22, č. 5 (2017), č. článku 834. E-ISSN 1420-3049
R&D Projects: GA ČR(CZ) GA16-12454S; GA MZd NV16-29835A
Institutional support: RVO:68081707
Keywords : colony-stimulating factor * total-body irradiation * enhance hematopoietic reconstitution
OECD category: Biophysics
Impact factor: 3.098, year: 2017

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irradiation treatment regimen. Many of the evaluated results show additivity, or even synergism, of the combined treatments in comparison with the effects of the individual component administrations. It can be deduced from these findings that the research in which combined treatments with radioprotectors/ radiomitigators are explored, tested, and evaluated is well-founded. The requirement for studies highly emphasizing the need to minimize undesirable side effects of the radioprotective/ radiomitigating therapies is stressed.
Permanent Link: http://hdl.handle.net/11104/0280683