Number of the records: 1
A novel, three-component reaction to the synthesis of 3-amino-4-cyano-5-aryl-1H-pyrrole-2-carboxamides
- 1.0485476 - FZÚ 2018 RIV GB eng J - Journal Article
Mohammadi, B. - Khorrami, B.R. - Ghorbani, M. - Dušek, Michal
A novel, three-component reaction to the synthesis of 3-amino-4-cyano-5-aryl-1H-pyrrole-2-carboxamides.
Tetrahedron. Roč. 73, č. 52 (2017), s. 7291-7294. ISSN 0040-4020. E-ISSN 1464-5416
Institutional support: RVO:68378271
Keywords : amidopyrrole * multi-component reaction * water * malononitrile * hydroxylamine hydrochloride
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.377, year: 2017
This work described a novel and efficient synthesis of 3-amino-4-cyano-5-phenyl-1H-pyrrole-2-carboxamides. The synthesis was carried out via a simple three-component reaction between arylidenmalononitrile, malononitrile and hydroxylamine hydrochloride in solvent-free conditions. Short reaction times, good to excellent yields of products, inexpensive and readily available starting material, and time and energy saving are the main advantages of this method. The structures of the products were confirmed by 1HNMR, 13CNMR, IR and single crystal X-ray analysis.
Permanent Link: http://hdl.handle.net/11104/0280490
Number of the records: 1