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Chromosomal damage as markers of genotoxic effect and carcinogenesis
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SYSNO ASEP 0475586 Document Type A - Abstract R&D Document Type O - Ostatní Title Chromosomal damage as markers of genotoxic effect and carcinogenesis Author(s) Vodička, Pavel (UEM-P) RID
Polívková, Z. (CZ)
Mušák, L. (SK)
Dušinská, M. (NO)
Vodenková, Soňa (UEM-P) ORCID, RID
Vymetálková, Veronika (UEM-P) RID
Kroupa, Michal (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Demová, H. (CZ)
Poláková, Veronika (UEM-P) RID
Ambruš, M. (CZ)
Kumar, R. (DE)
Hemminki, K. (DE)Source Title Prague Medical Report. - : Nakladatelství Karolinum - ISSN 1214-6994
Roč. 116, č. 2015 (2015), s. 56-63Number of pages 7 s. Action 15th Central European Lung Cancer Conference including Best of WCLC 2015 Event date 28.11.2015 - 30.11.2015 VEvent location Praha Country CZ - Czech Republic Language eng - English Country CZ - Czech Republic Keywords chromosomal aberrations ; malignant transformation ; incident cancer patients ; cancer risk ; CIN ; DNA repair Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP304/12/1585 GA ČR - Czech Science Foundation (CSF) GA15-14789S GA ČR - Czech Science Foundation (CSF) NT14329 GA MZd - Ministry of Health (MZ) NT14056 GA MZd - Ministry of Health (MZ) LH13061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LD14050 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 Annotation Many cancers often arise from cells unable to maintain genomic and chromosomal instability. Recurrent chromosomal aberrations (CAs) arise through a clonal growth of cells with specific translocations, deletions or amplifications of chromosomal regions or whole chromosomes and many specific CAs are causative events in malignant transformation. In our studies we compared frequencies of CAs in patients with incident lung, breast and colorectal cancer. Additionally, we have also searched for genetic background that modulates chromosomal instability in humans. The DNA repair characteristics have been discussed as well. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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