Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

0463320 - MBÚ 2017 RIV US eng J - Journal Article
Schwarzer, Martin - Makki, K. - Storelli, G. - Machuca-Gayet, I. - Šrůtková, Dagmar - Hermanová, Petra - Martino, M.E. - Balmand, S. - Hudcovic, Tomáš - Heddi, A. - Rieusset, J. - Kozáková, Hana - Vidal, H. - Leulier, F.
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition.
Science. Roč. 351, č. 6275 (2016), s. 854-857. ISSN 0036-8075. E-ISSN 1095-9203
R&D Projects: GA ČR(CZ) GAP303/12/0535
Institutional support: RVO:61388971
Keywords : FACTOR-I * SOMATOTROPIC AXIS * BODY GROWTH
Subject RIV: EC - Immunology
Impact factor: 37.205, year: 2016

In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growt
Permanent Link: http://hdl.handle.net/11104/0262539