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Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia
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SYSNO ASEP 0444821 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia Author(s) Holzerová, K. (CZ)
Hlaváčková, Markéta (FGU-C) RID, ORCID
Žurmanová, J. (CZ)
Borchert, Gudrun H. (FGU-C)
Neckář, Jan (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAI
Novák, F. (CZ)
Nováková, O. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, č. 2 (2015), s. 191-201Number of pages 11 s. Language eng - English Country CZ - Czech Republic Keywords chronic hypoxia ; cardioprotection ; ventricular myocytes ; protein kinase C ; PKC epsilon inhibitory peptide KP-1633 Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects GAP303/12/1162 GA ČR - Czech Science Foundation (CSF) GA13-10267S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000357409400006 EID SCOPUS 84930160840 Annotation The aim of this study was to analyse the expression of PKC epsilon after the adaptation to chronic continuous hypoxia (CNH) and to clarify its role in increased cardiac ischemic tolerance with the use of PKC epsilon inhibitory peptide KP-1633. Adaptation to CNH increased myocardial PKC epsilon at protein and mRNA levels. The application of KP-1633 blunted the hypoxia-induced salutary effects on cell viability and LDH release, while control peptide KP-1723 had no effect. This study indicates that PKC epsilon is involved in the cardioprotective mechanism induced by CNH Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
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