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A thermodynamic model of bone remodelling: The influence of dynamic loading together with biochemical control
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SYSNO ASEP 0438609 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A thermodynamic model of bone remodelling: The influence of dynamic loading together with biochemical control Author(s) Klika, Václav (UT-L) RID
Maršík, František (UT-L) RIDSource Title Journal of Musculoskeletal Interactions - ISSN 1108-7161
Roč. 10, č. 3 (2010), s. 220-230Number of pages 11 s. Publication form Print - P Language eng - English Country GR - Greece Keywords bone remodelling ; chemical kinetics ; dynamic loading Subject RIV FI - Traumatology, Orthopedics R&D Projects GA106/08/0557 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000282051300005 EID SCOPUS 77957330175 Annotation Understanding of the bone remodelling process has considerably increased during the last 20 years. Since the ability to simulate (and predict) the effects of bone remodelling offers substantial insights, several models have been proposed to describe this phenomenon. The strength of the presented model is that it includes biochemical control factors (e.g., the necessity of cell-to-cell contact, which is mediated by the RANKL-RANK-OPG chain during osteoclastogenesis) and mechanical stimulation, the governing equations are derived from interaction kinetics (e.g., mass is preserved in running reactions), and the parameters are measurable. Behaviour of the model is in accordance with experimental and clinical observations, such as the role of dynamic loading, the inhibitory effect of dynamic loading on osteoclastogenesis, the observation that polykaryon osteoclasts are activated and formed by a direct cell-to-cell contact, and the correct concentrations of osteoblasts, osteoclasts, and osteocytes. The model does not yet describe the bone remodelling process in complete detail, but the implemented simplifications describe the key features and further details of control mechanisms may be added. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2015
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