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TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia
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SYSNO ASEP 0428171 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia Author(s) Špicarová, Diana (FGU-C) RID, ORCID
Adámek, Pavel (FGU-C) RID, ORCID, SAI
Kalynovska, Nataliia (FGU-C) ORCID, RID
Mrózková, Petra (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCIDSource Title Neuropharmacology. - : Elsevier - ISSN 0028-3908
Roč. 81, JUN (2014), s. 75-84Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords pain ; spinal cord ; synaptic transmission ; CCL2 ; TRPV1 ; EPSC Subject RIV FH - Neurology R&D Projects GA305/09/1228 GA ČR - Czech Science Foundation (CSF) GPP303/12/P510 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) LH12058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000335632400008 EID SCOPUS 84894279054 DOI 10.1016/j.neuropharm.2014.01.041 Annotation Modulation of nociceptive synaptic transmission in the spinal cord is implicated in the development and maintenance of several pathological pain states. The chemokine CCL2 (CeC motif ligand 2) was shown to be an important factor in the development of neuropathic pain after peripheral nerve injury. In our experiments we have studied the effect of CCL2 application and TRPV1 (transient receptor potential vanilloid 1) receptor activation on nociceptive signaling and the modulation of synaptic transmission. Our results demonstrate that the activation of spinal TRPV1 receptors plays an important role in the modulation of nociceptive signaling induced by CCL2 application. The mechanisms of cooperation between the CCL2 activated receptors and TRPV1 receptors on the central branches of primary afferent fibers may be especially important during different pathological pain states and need to be further investigated Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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