Asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type Ru(II) complex-a parametric study

0425834 - MBÚ 2014 RIV GB eng J - Journal Article
Pecháček, J. - Václavík, J. - Přech, J. - Šot, P. - Januščák, J. - Vilhanová, B. - Vavřík, J. - Kuzma, Marek - Kačer, P.
Asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type Ru(II) complex-a parametric study.
Tetrahedron Asymmetry. Roč. 24, č. 4 (2013), s. 233-239. ISSN 0957-4166
R&D Projects: GA ČR GA104/09/1497; GA ČR GAP106/12/1276
Grant - others:GA MŠk(CZ) LM2010005
Institutional support: RVO:61388971
Keywords : LIGAND BIFUNCTIONAL CATALYSIS * CARBONYL-COMPOUNDS * FORMIC-ACID
Subject RIV: CA - Inorganic Chemistry
Impact factor: 2.165, year: 2013

We present, to the best of our knowledge, the first parametric study of the asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type catalytic complex based on ruthenium. A model imine for this study was 1-methyl-3,4-dihydroisoquinoline, and a well-known complex RuCl(eta(6)-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine) was chosen as the model catalyst. The reactions were performed in the presence of a formic acid-triethylamine mixture as the source of hydrogen. The parameters examined include general parameters, for example, concentration, temperature, and substrate-to-catalyst molar ratio, as well as parameters specific to this particular reaction, such as the amount of the hydrogenation mixture used, the ratio of its components, or the inhibitive effect of carbon dioxide. During this study, several unexpected parameters worth further investigation have emerged.
Permanent Link: http://hdl.handle.net/11104/0231671