A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs

Filová, Eva; Rampichová, Michala; Litvinec, Andrej; Držík, M.; Míčková, Andrea; Buzgo, Matej; Košťáková, E.; Martinová, L.; Usvald, Dušan; Prosecká, Eva; Uhlík, J.; Motlík, Jan; Vajner, L.; Amler, Evžen

doi:https://dx.doi.org/10.1016/j.ijpharm.2013.02.056

Number of the records: 1

A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs

1.

SYSNO ASEP	0397648
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs
Author(s)	Filová, Eva (UEM-P)_{RID, ORCID} Rampichová, Michala (UEM-P)_{RID, ORCID} Litvinec, Andrej (UEM-P) Držík, M. (SK) Míčková, Andrea (UEM-P) Buzgo, Matej (UEM-P) Košťáková, E. (CZ) Martinová, L. (CZ) Usvald, Dušan (UZFG-Y) Prosecká, Eva (UEM-P) Uhlík, J. (CZ) Motlík, Jan (UZFG-Y)_{RID, ORCID} Vajner, L. (CZ) Amler, Evžen (UEM-P)_RID
Number of authors	14
Source Title	International Journal of Pharmaceutics. - : Elsevier - ISSN 0378-5173 Roč. 447, 1-2 (2013), s. 139-149
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	cartilage ; fibrin ; nanofibers
Subject RIV	FP - Other Medical Disciplines
Subject RIV - cooperation	Institute of Animal Physiology and Genetics - Other Medical Disciplines
R&D Projects	GAP304/10/1307 GA ČR - Czech Science Foundation (CSF)
Institutional support	UZFG-Y - RVO:67985904 ; UEM-P - RVO:68378041
CEZ	AV0Z50390703 - UEM-P (2007-2013)
	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000317310500017
EID SCOPUS	84875083803
DOI	10.1016/j.ijpharm.2013.02.056
Annotation	A novel drug delivery system was developed on the basis of the intake effect of liposomes encapsulated in PVA nanofibers. Time-controlled release of insulin and bFGF improved MSC viability in vitro. In addition, cell-free composite scaffolds containing PVA nanofibers enriched with liposomes, bFGF, and insulin were implanted into seven osteochondral defects of miniature pigs; control defects were left untreated. The cell-free composite scaffold enhanced migration of the cells into the defect, and their differentiation into chondrocytes; the scaffold was able to enhance the regeneration of osteochondral defects in minipigs.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2014

Number of the records: 1