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The structure and material composition of ossified aortic valves identified using a set of scientific methods
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SYSNO ASEP 0397509 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The structure and material composition of ossified aortic valves identified using a set of scientific methods Author(s) Zeman, Antonín (UTAM-F) RID, SAI
Šmíd, M. (CZ)
Havelcová, Martina (USMH-B) RID, ORCID
Coufalová, L. (CZ)
Kučková, S. (CZ)
Velčovská, M. (CZ)
Hynek, R. (CZ)Number of authors 7 Source Title Journal of Asian Earth Sciences. - : Elsevier - ISSN 1367-9120
Roč. 77, November (2013), s. 311-317Number of pages 7 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords aortic stenosis ; degenerative (calcification–sclerotic) changes ; hydroxyapatite ; proteins ; cholesterol Subject RIV DB - Geology ; Mineralogy Institutional support UTAM-F - RVO:68378297 ; USMH-B - RVO:67985891 UT WOS 000326996800030 EID SCOPUS 84885476900 DOI 10.1016/j.jseaes.2013.07.001 Annotation Degenerative aortic stenosis has become a common and dangerous disease in recent decades. This disease leads to the mineralization of aortic valves, their gradual thickening and loss of functionality. We studied the detailed assessment of the proportion and composition of inorganic and organic components in the ossified aortic valve, using a set of analytical methods applied in science: polarized light microscopy, scanning electron microscopy, X-ray fluorescence, X-ray diffraction, gas chromatography/mass spectrometry and liquid chromatography–tandem mass spectrometry. The sample valves showed the occurrence of phosphorus and calcium in the form of phosphate and calcium carbonate, hydroxyapatite, fluorapatite and hydroxy-fluorapatite, with varying content of inorganic components from 65 to 90 wt%, and with phased development of degenerative disability. The outer layers of the plaque contained an organic component with peptide bonds, fatty acids, proteins and cholesterol. Workplace Institute of Theoretical and Applied Mechanics Contact Kulawiecová Kateřina, kulawiecova@itam.cas.cz, Tel.: 225 443 285 Year of Publishing 2014 Electronic address http://www.sciencedirect.com/science/journal/13679120/77
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