Number of the records: 1
Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons
- 1.
SYSNO ASEP 0394726 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons Author(s) Cocks, G. (GB)
Romanyuk, Nataliya (UEM-P) RID
Amemori, Takashi (UEM-P) RID
Jendelová, Pavla (UEM-P) RID, ORCID
Forostyak, Oksana (UEM-P)
Jeffries, A. R. (GB)
Perfect, L. (GB)
Thuret, S. (GB)
Dayanithi, Govindan (UEM-P) RID
Syková, Eva (UEM-P) RID
Price, J. (GB)Number of authors 11 Source Title Stem Cell Research & Therapy. - : BioMed Central
Roč. 4, č. 3 (2013), s. 69Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords neural stem cells ; spinal cord ; motoneurons Subject RIV FH - Neurology R&D Projects IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP304/11/2373 GA ČR - Czech Science Foundation (CSF) GA13-00939S GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000320865700001 EID SCOPUS 84878646860 DOI 10.1186/scrt220 Annotation Clonal neural stem cell lines were derived from 10-week-old human fetal spinal cord and conditionally immortalized with an inducible form of cMyc. Clonal lines retain a clear transcriptional signature of ventral spinal cord progenitors, differentiate into relevant ventral neuronal subtypes with functional T-, L-, N-, and P/Q-type Ca2+ channels and spontaneous calcium oscillations, and stably engraft into lesioned rat spinal cord without tumorogenicity. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2014
Number of the records: 1