Number of the records: 1
Adhesion and Growth of Vascular Smooth Muscle Cells on Nanostructured and Biofunctionalized Polyethylene
- 1.0392341 - FGÚ 2014 RIV CH eng J - Journal Article
Novotná, Katarína - Bačáková, Markéta - Kasálková-Slepičková, N. - Slepička, P. - Lisá, Věra - Švorčík, V. - Bačáková, Lucie
Adhesion and Growth of Vascular Smooth Muscle Cells on Nanostructured and Biofunctionalized Polyethylene.
Materials. Roč. 6, č. 5 (2013), s. 1632-1655. E-ISSN 1996-1944
R&D Projects: GA ČR(CZ) GBP108/12/G108
Institutional support: RVO:67985823
Keywords : plasma treatment * biocompatibility * fibronectin * tissue engineering
Subject RIV: JJ - Other Materials
Impact factor: 1.879, year: 2013
Cell colonization of synthetic polymers can be regulated by physical and chemical modifications of the polymer surface. High-density and low-density polyethylene (HDPE and LDPE) were activated with Ar+ plasma and grafted with fibronectin (Fn) or bovine serum albumin (BSA). Plasma treatment and grafting with Fn or BSA improved the adhesion and growth of vascular smooth muscle cells in a serum-supplement mdium. The final cell ppulation densities on day 6 after seeding were on an average higher on LDPE than on HDPE. In a serum-free medium, BSA grafted to the polymer surface hampered cell adhesion. Thus, the cell behavior on polyethylene can be modulated by its type, intensity of plasma modification, grafting with biomolecules, and composition of the culture medium
Permanent Link: http://hdl.handle.net/11104/0221242
Number of the records: 1