Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

Jabůrek, Martin; Ježek, Jan; Zelenka, Jaroslav; Ježek, Petr

doi:https://dx.doi.org/10.1016/j.biocel.2013.01.010

Number of the records: 1

Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

1.

SYSNO ASEP	0391725
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen
Author(s)	Jabůrek, Martin (FGU-C)_{ORCID, RID} Ježek, Jan (FGU-C)_{RID, ORCID} Zelenka, Jaroslav (FGU-C)_RID Ježek, Petr (FGU-C)_{RID, ORCID}
Source Title	International Journal of Biochemistry and Cell Biology. - : Elsevier - ISSN 1357-2725 Roč. 45, č. 4 (2013), s. 816-825
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	mitochondrial uncoupling protein UCP2 ; mitochondrial phospholipase A(2) isoform gamma ; mitochondrial oxidative stress attenuation ; fatty acid ; antioxidant mechanism
Subject RIV	ED - Physiology
R&D Projects	GAP302/10/0346 GA ČR - Czech Science Foundation (CSF)
	GPP303/11/P320 GA ČR - Czech Science Foundation (CSF)
	ME09018 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000317371300007
EID SCOPUS	84873700347
DOI	10.1016/j.biocel.2013.01.010
Annotation	Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we tested the hypothesis that UCP2 provides feedback downregulation of oxidative stress in vivo via synergy with an H2O2-activated mitochondrial calcium-independent phospholipase A2 (mt-iPLA2). In this article we demonstarte for the first time that UCP2, functional due to fatty acids released by redox-activated mt-iPLA2gamma, suppresses mitochondrial superoxide production by its uncoupling action. In conclusion, H2O2-activated mt-iPLA2gamma and UCP2 act in concert to protect against oxidative stress
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2014

Number of the records: 1