Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development

0386188 - ÚŽFG 2013 RIV DK eng J - Journal Article
Lungová, Vlasta - Buchtová, Marcela - Janečková, Eva - Tucker, A.S. - Knopfová, L. - Šmarda, J. - Matalová, Eva
Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development.
European Journal of Oral Sciences. Roč. 120, č. 6 (2012), 495-504. ISSN 0909-8836. E-ISSN 1600-0722
R&D Projects: GA ČR GCP302/12/J059
Institutional research plan: CEZ:AV0Z50450515
Keywords : c-myb * tooth * postnatal
Subject RIV: FF - HEENT, Dentistry
Impact factor: 1.420, year: 2012

The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
Permanent Link: http://hdl.handle.net/11104/0220157