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The serotonergic system in ageing and Alzheimer's disease.
- 1.0385396 - ÚEM 2013 RIV GB eng J - Journal Article
Rodríguez Arellano, Jose Julio - Noristani, H. N. - Verkhratsky, A.
The serotonergic system in ageing and Alzheimer's disease.
Progress in Neurobiology. Roč. 99, č. 1 (2012), s. 15-41. ISSN 0301-0082. E-ISSN 1873-5118
R&D Projects: GA ČR GA309/09/1696; GA ČR GA305/08/1384; GA ČR GA309/08/1381; GA ČR(CZ) GAP304/11/0184
Institutional research plan: CEZ:AV0Z50390703
Institutional support: RVO:68378041
Keywords : dementia * serotonin * hippocampus
Subject RIV: FH - Neurology
Impact factor: 9.035, year: 2012
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates cognitive functions and primarily affects associated brain regions involved in learning and memory, such as the neocortex and the hippocampus. We present a comprehensive overview of the role of serotonergic neurotransmission in brain development, maturation and ageing, discuss its role in higher brain function and provide an in depth account of pathological modifications of serotonergic transmission in neurological diseases and AD.
Permanent Link: http://hdl.handle.net/11104/0215098
Number of the records: 1