Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system

Jäger, Eliezer; Jäger, Alessandro; Etrych, Tomáš; Giacomelli, F. C.; Chytil, Petr; Jigounov, Alexander; Putaux, J.-L.; Říhová, Blanka; Ulbrich, Karel; Štěpánek, Petr

doi:https://dx.doi.org/10.1039/c2sm26150b

Number of the records: 1

Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system

1.

SYSNO ASEP	0379960
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system
Author(s)	Jäger, Eliezer (UMCH-V)_{ORCID, RID} Jäger, Alessandro (UMCH-V)_{RID, ORCID} Etrych, Tomáš (UMCH-V)_{RID, ORCID} Giacomelli, F. C. (BR) Chytil, Petr (UMCH-V)_{RID, ORCID} Jigounov, Alexander (UMCH-V)_{RID, ORCID} Putaux, J.-L. (FR) Říhová, Blanka (MBU-M)_RID Ulbrich, Karel (UMCH-V)_RID Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Source Title	Soft Matter - ISSN 1744-683X Roč. 8, č. 37 (2012), s. 9563-9575
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	biodegradable nanoparticles ; light scattering from polymer nanoparticles ; doxorubicin drug release
Subject RIV	CF - Physical ; Theoretical Chemistry
Subject RIV - cooperation	Institute of Microbiology - Immunology
R&D Projects	IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP208/10/1600 GA ČR - Czech Science Foundation (CSF)
Institutional support	UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000308095700010
DOI	10.1039/c2sm26150b
Annotation	The surface modification of nanoparticles by physically anchoring hydrophilic biocompatible polymers is a simple and commercially attractive strategy to produce stealth drug delivery nanocarriers. Herein, we report the preparation, characterization and preliminary evaluation of the biological behaviour of polymeric nanoparticles (NPs) comprising a biodegradable poly(butylene succinate-co-butylene dilinoleate) – PBS/PBDL – copolyester and a non-immunogenic and non-toxic hydrophilic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer. Narrowly distributed sub-100 nm polymeric nanoparticles with stealth properties were successfully prepared by using a combination of interfacial nanoprecipitation and self-assembly. The assemblies were characterized by using complementary scattering techniques and cryo-transmission electron microscopy.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2013

Number of the records: 1