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Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level
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SYSNO ASEP 0373453 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level Author(s) Paleček, Emil (BFU-R) RID, ORCID
Ostatná, Veronika (BFU-R) RID, ORCID
Černocká, Hana (BFU-R) RID, ORCID
Joerger, A.C. (GB)
Fersht, A.R. (GB)Number of authors 5 Source Title Journal of the American Chemical Society. - : American Chemical Society - ISSN 0002-7863
Roč. 133, č. 18 (2011), s. 7190-7196Number of pages 7 s. Language eng - English Country US - United States Keywords p53 ; conformational changes ; constant current chronopotentiometric stripping (CPS) Subject RIV BO - Biophysics R&D Projects KAN400310651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KJB100040901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000290885100051 DOI 10.1021/ja201006s Annotation CPS on dithiothreitol-modified mercury electrodes enabled distinguishing of wt- and mutant of the tumor suppressor p53. Moreover, it was possible to monitor the loss of an essential zinc ion. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2012
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