A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice

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SYSNO ASEP	0365878
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice
Author(s)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Weiterová, Lenka (BFU-R)_RID
Number of authors	5
Source Title	Radiation Research. - : Radiation Research Society - ISSN 0033-7587 Roč. 176, č. 2 (2011), s. 269-272
Number of pages	4 s.
Language	eng - English
Country	US - United States
Keywords	cyclooxygenase-2 inhibition ; lethal irradiation ; survival
Subject RIV	BO - Biophysics
R&D Projects	GA305/08/0158 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000293682100014
DOI	10.1667/RR2614.1
Annotation	We have found that meloxicam, a cyclooxygenase-2 inhibitor, administered in a single dose shortly, i.e. 1 hour, after lethal irradiation, increases survival of irradiated mice. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1