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Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy
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SYSNO ASEP 0351895 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy Author(s) Kappen, C. (US)
Pavlínková, Gabriela (BTO-N) RID, ORCID
Kruger, C. (US)
Salbaum, M. (US)Source Title Birth Defects Research Part A-Clinical and Molecular Teratology - ISSN 1542-0752
Roč. 85, č. 5 (2009), s. 410-410Number of pages 1 s. Language eng - English Country US - United States Keywords Embryopathy ; microarrays ; placenta Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520701 - BTO-N (2007-2013) Annotation Diabetes during pregnancy is a known risk factor for congenital malformations of the cardiovascular system and for neural tube defects. Using genome-wide expression prolifing, we have shown that the exposure is associated with deregulated gene expression in the developing embryo. Altered gene expression was also evident in the diabetic placenta, where a different repertoire of genes is misexpressed. This indicates that responses to metabolic imbalance employ specific pathways in tissue- and cell-type-specific manner, thus implicating multiple and distinct gene-environment interactions in birth defects risk under conditions of diabetic pregnancy. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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