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Temporal variation in the genotoxic potential of urban air particulate matter
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SYSNO ASEP 0342078 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Temporal variation in the genotoxic potential of urban air particulate matter Title Časová variabilita genotoxického potenciálu prachových částic v městském ovzduší Author(s) Sevastyanova, Oksana (UEM-P)
Nováková, Zuzana (UEM-P)
Hanzalová, K. (CZ)
Binková, Blanka (UEM-P)
Šrám, Radim (UEM-P) RID
Topinka, Jan (UEM-P) RID, ORCIDSource Title Mutation Research - Genetic Toxicology and Environmental Mutagenesis. - : Elsevier - ISSN 1383-5718
Roč. 649, 1-2 (2008), s. 179-186Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords DNA adducts ; Carcinogenesis PAHs ; Air particles Subject RIV DN - Health Impact of the Environment Quality R&D Projects SL/5/160/05 GA MŽP - Ministry of Environment (MŽP) UT WOS 252795800019 DOI 10.1016/j.mrgentox.2007.09.010 Annotation DNA adduct forming activity of extractable organic matter (EOM) from urban air particles <10µm (PM10) was analyzed in human hepatoma cell line HepG2. The results suggest that the estimation of the genotoxic potential of ambient air and prediction of health risk should be based mainly on c-PAHs concentration and biological activity of extracts, while amount of particles and EOM content do not seem to be crucial determinants of ambient air genotoxicity. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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