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Hexabromocyclododecane but not tetrabromobisphenol A
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SYSNO ASEP 0341125 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Hexabromocyclododecane but not tetrabromobisphenol A Author(s) Dorosh, Andriy (BTO-N) RID
Děd, Lukáš (BTO-N) RID
Elzeinová, Fatima (BTO-N) RID
Pěknicová, Jana (BTO-N) RIDNumber of authors 4 Source Title Journal of Reproductive Immunology. - : Elsevier - ISSN 0165-0378
Roč. 81, č. 2 (2009), s. 153-153Number of pages 1 s. Action 7th European Congress on Reproductive Immunology Event date 17.09.2009-20.09.2009 VEvent location Marathon Country GR - Greece Event type WRD Language eng - English Country US - United States Keywords estrogen ; polybrominated compounds ; TFF- 1 ; cell proliferation Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GD523/08/H064 GA ČR - Czech Science Foundation (CSF) GA523/09/1793 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) Annotation In this study, we performed MCF-7 proliferation assay and the gene expression analysis of the TFF1 reporter gene. The cell line was exposed to three natural hormones (estrone (E1), 17β-estradiol (E2), and estriol (E3)), one synthetic hormone (17α-ethinylestradiol (EE2)) and two polybrominated compounds (tetrabromobysphenol A (TBBPA) and hexabromocyclododecane (HBCD)). We confirmed the concentration-dependent increase in the cell proliferation and TFF1 gene expression after exposure the MCF-7 cells with estrogen. Further, we found that HBCD but not TBBPA has estrogenic effect on MCF-7 cells in vitro. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2010
Number of the records: 1