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Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?
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SYSNO ASEP 0318750 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer? Title Ovlivňují polymorfismy a haplotypa mismatch reparačních genů riziko sporadické formy nádorů tlustého střeva a konečníku? Author(s) Tulupová, Elena (UEM-P)
Kumar, R. (DE)
Hánová, Monika (UEM-P)
Slyšková, Jana (UEM-P) RID
Pardini, Barbara (UEM-P)
Poláková, Veronika (UEM-P) RID
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Novotný, J. (DE)
Halamková, J. (CZ)
Hemminki, K. (DE)
Vodička, Pavel (UEM-P) RIDSource Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 648, 1-2 (2008), s. 40-45Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords DNA mismatch repair ; Genetic polymorphism ; Haplotype analysis Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/07/1430 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000261797000006 DOI 10.1016/j.mrfmmm.2008.09.005 Annotation The Czech Republic presents one of the highest incidences of colorectal cancer in the world. We genotyped 10 single nucleotide polymorphisms in five DNA mismatch repair genes in 614 colorectal cancer cases and 614 matched controls from this country. Our data suggest a limited role for the investigated individual variants in mismatch repair genes for the susceptibility to the disease. The haplotypes covering hMSH6 gene may, however, be involved in risk modulation in this population. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2009
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