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Genome-Wide Co-Expression Analysis in Multiple Tissues
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SYSNO ASEP 0318235 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Genome-Wide Co-Expression Analysis in Multiple Tissues Title Celogenomová koexpresní analýza v několika tkáních Author(s) Grieve, I.C. (GB)
Dickens, N. J. (GB)
Pravenec, Michal (FGU-C) RID, ORCID
Křen, Vladimír (FGU-C)
Hubner, N. (DE)
Cook, S.A. (GB)
Aitman, T. J. (GB)
Petretto, E. (GB)
Mangion, J. (GB)Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 3, č. 12 (2008), e4033-e4033Number of pages 11 s. Language eng - English Country US - United States Keywords Cis- and trans-eQTL ; coexpression analysis in multiple tissues ; recombinant inbred strains Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1P05ME791 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA301/06/0028 GA ČR - Czech Science Foundation (CSF) GA301/08/0166 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis and trans-acting, reflecting local and distant regulation of gene expression respectively. We have mapped thousands of cis- and trans-eQTLs in four tissues (fat, kidney, adrenal and left ventricle) in a large panel of rat recombinant inbred (RI) strains. Here we investigate the genome-wide correlation structure in expression levels of eQTL transcripts and underlying genotypes to elucidate the nature of co-regulation within cis- and trans-eQTL datasets Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2009
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