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J3-crystallin of the jellyfish lens: similarity to saposins
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SYSNO ASEP 0191342 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title J3-crystallin of the jellyfish lens: similarity to saposins Author(s) Piatigorsky, J. (US)
Norman, B. (US)
Dishaw, L. J. (US)
Kos, L. (US)
Horwitz, J. (CA)
Steinbach, P. J. (US)
Kozmik, Zbyněk (UMG-J) RIDSource Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 98, č. 22 (2001), s. 12362-12367Number of pages 6 s. Language eng - English Country US - United States Keywords crystallin ; jellyfish ; lens Subject RIV EB - Genetics ; Molecular Biology R&D Projects LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Annotation J3-crystallin, one of the three major eye-lens proteins of the cubomedusan jellyfish (Tripedalia cystophora), shows similarity to vertebrate saposins, which are multifunctional proteins that bridge lysosomal hydrolases to lipids and activate enzyme activity. Our data suggest a crystallin role for the multifunctional saposin protein family in the jellyfish lens. This finding extends the gene sharing evolutionary strategy for lens crystallins to the cnidarians. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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