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Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
- 1.0126451 - BFU-R 20013011 RIV GB eng J - Journal Article
Dvořáková, D. - Krejčí, P. - Mayer, J. - Fajkus, Jiří - Hampl, Aleš - Dvořák, Petr
Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells.
British Journal of Haematology. Roč. 113, č. 3 (2001), s. 832-835. ISSN 0007-1048. E-ISSN 1365-2141
R&D Projects: GA ČR GA312/97/0393; GA MŠMT ME 198
Institutional research plan: CEZ:AV0Z5045916
Keywords : fibroblast growth factor receptor 3 * chronic myeloid leukaemia * stem cell transplantation
Subject RIV: BO - Biophysics
Impact factor: 2.815, year: 2001
Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells. After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia
Permanent Link: http://hdl.handle.net/11104/0024680
Number of the records: 1