0087416 - ÚOCHB 2008 RIV FR eng J - Journal Article
Fragiadaki, M. - Magafa, V. - Borovičková, Lenka - Slaninová, Jiřina - Cordopatis, P.
Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7.
[Analoga oxytocinu obsahující konformačně omezené aminokyselinové zbytky v posici 7.]
European Journal of Medicinal Chemistry. Roč. 42, č. 6 (2007), s. 799-806. ISSN 0223-5234. E-ISSN 1768-3254
Institutional research plan: CEZ:AV0Z40550506
Keywords : oxytocin analogues * position 7 * biological activity
Subject RIV: CE - Biochemistry
Impact factor: 2.301, year: 2007
DOI: https://doi.org/10.1016/j.ejmech.2006.12.016

Solid-phase synthesis and some pharmacological properties of twenty new oxytocin analogues are described. Analogues are modified in position 7 by introduction of alpha-aminoisobutyric acid [Aib], L- or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid [L/D-Tic], L-alpha-t-butylglycine [Gly(Bu(t))] and pipecolic acid [Pip].

Popsána syntéza a některé biologické aktivity 20 nových analogů oxytocinu s hlavní modifikací v poloze 7 substituce prolinu alpha-aminoisomáselnou kyselinou[Aib], L- or D-1,2,3,4-tetrahydroisoquinolinovou -3-karboxylovou kyselinou [L/D-Tic], L-alpha-t-butylglycinem [Gly(Bu(t))] a kyselinou pipekolovou [Pip].

Permanent Link: http://hdl.handle.net/11104/0149266