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Mutant p53 proteins bind selectively supercoiled DNA
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SYSNO ASEP 0084172 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Mutant p53 proteins bind selectively supercoiled DNA Title Mutantní proteiny p53 se selektivně váží k nadšroubovicové DNA Author(s) Němcová, Kateřina (BFU-R)
Brázdová, Marie (BFU-R) RID, ORCID
Činčárová, Lenka (BFU-R)
Šebest, Peter (BFU-R) ORCID
Pivoňková, Hana (BFU-R) ORCID
Tichá, Olga (BFU-R)
Fojta, Miroslav (BFU-R) RID, ORCID
Paleček, Emil (BFU-R) RID, ORCIDSource Title Abstracts-FEBS-J. - Vienna, 2007
S. 154Number of pages 1 s. Action 32nd FEBS Congress - Molecular Machines Event date 07.07.2007-12.07.2007 VEvent location Vienna Country AT - Austria Event type EUR Language eng - English Country AT - Austria Keywords Mutp53 ; SCS DNA binding ; p53CON Subject RIV BO - Biophysics R&D Projects 1K04119 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP204/06/P369 GA ČR - Czech Science Foundation (CSF) IAA500040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation DNA interactions of full-length mutant p53 proteins (mutp53) (R175H, G245S, R248W, R273H, R273C) were studied. Some of the mutp53s exhibited significant binding to p53CON in 500bp DNA fragments. Competition assays and selective manipulation of the central and/or C-terminal DNA binding domains of the mutp53s revealed critical role of the C-terminal domain in the SCS binding. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2008
Number of the records: 1