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Atorvastatin slows down the deterioration of inner ear function with age in mice
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SYSNO ASEP 0045387 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Atorvastatin slows down the deterioration of inner ear function with age in mice Title Atorvastatin zpomaluje s věkem související poškození vnitřního ucha u myši Author(s) Syka, Josef (UEM-P) RID
Ouda, Ladislav (UEM-P) RID
Nachtigal, P. (CZ)
Solichová, D. (CZ)
Semecký, V. (CZ)Source Title Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 411, č. 2 (2007), s. 112-116Number of pages 5 s. Language eng - English Country IE - Ireland Keywords Statins ; Presbycusis ; Distortion product otoacoustic emission Subject RIV FH - Neurology R&D Projects GA309/04/1074 GA ČR - Czech Science Foundation (CSF) NR8113 GA MZd - Ministry of Health (MZ) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP304/03/P049 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) Annotation In C57BL/6J mice, a strain with accelerated aging, we demonstrated that animals treated with atorvastatin for 2 months showed larger amplitudes of distortion product otoacoustic emissions (DPOAE) than did the non-treated control group. This finding indicates a better survival of outer hair cell function in the inner ear and suggests that statins could also slow down the age-related deterioration of hearing in man. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2007
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