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Strong structural and electronic binding of bovine serum albumin to ZnO via specific amino acid residues and zinc atoms
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SYSNO ASEP 0561891 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Strong structural and electronic binding of bovine serum albumin to ZnO via specific amino acid residues and zinc atoms Author(s) Hematian, H. (CZ)
Ukraintsev, Egor (FZU-D) RID, ORCID
Rezek, B. (CZ)Number of authors 3 Source Title ChemPhysChem. - : Wiley - ISSN 1439-4235
Roč. 23, č. 2 (2022), s. 25-33Number of pages 10 s. Language eng - English Country DE - Germany Keywords bovine serum albumin ; ZnO ; atomic force microscopy ; nanoshaving ; density-functional tight-binding Subject RIV CD - Macromolecular Chemistry OECD category Fluids and plasma physics (including surface physics) R&D Projects GC19-02858J GA ČR - Czech Science Foundation (CSF) Research Infrastructure CzechNanoLab - 90110 - Vysoké učení technické v Brně Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000722264500001 EID SCOPUS 85119672612 DOI 10.1002/cphc.202100639 Annotation ZnO biointerfaces with serum albumin have attracted noticeable attention due to the increasing interest in developing ZnO-based materials for biomedical applications. ZnO surface morphology and chemistry are expected to play a critical role on the structural, optical, and electronic properties of albumin-ZnO complexes. Yet there are still large gaps in the understanding of these biological interfaces. Herein we comprehensively elucidate the interactions at such interfaces by using atomic force microscopy and nanoshaving experiments to determine roughness, thickness, and adhesion properties of BSA layers adsorbed on the most typical polar and non-polar ZnO single-crystal facets. These experiments are corroborated by force field (FF) and DFTB calculations on ZnO-BSA interfaces. We show that BSA adsorbs on all the studied ZnO surfaces while interactions of BSA with ZnO are found to be considerably affected by the atomic surface structure of ZnO.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2023 Electronic address https://doi.org/10.1002/cphc.202100639
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