PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

0561656 - ÚMG 2023 RIV GB eng J - Journal Article
Zhao, X. - Bartholdy, B. - Yamamoto, Y. - Evans, E. K. - Alberich-Jorda, Meritxell - Staber, P.B. - Benoukraf, T. - Zhang, P. - Zhang, J. - Trinh, B. Q. - Crispino, J. D. - Hoang, T. - Bassal, M. A. - Tenen, D.G.
PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development.
Communications Biology. Roč. 5, č. 1 (2022), č. článku 961. E-ISSN 2399-3642
Institutional support: RVO:68378050
Keywords : TRANSCRIPTION FACTOR PU.1 * C-JUN EXPRESSION * MACROPHAGE DIFFERENTIATION * PROTEIN-PROTEIN * GENE-EXPRESSION * STEM-CELLS * REGULATES EXPRESSIONGATA-1 * DNA * RECEPTOR
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impact factor: 5.9, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s42003-022-03888-7

The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including macrophages and B cells.
Permanent Link: https://hdl.handle.net/11104/0338624