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Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis
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SYSNO ASEP 0561031 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis Author(s) Syková, E. (SK)
Čížková, D. (SK)
Kubinová, Šárka (FZU-D) RID, ORCIDNumber of authors 3 Article number 695900 Source Title Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 9, July (2021)Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords mesenchymal stem cells ; cell therapy ; spinal cord injury ; amyotrophic lateral sclerosis ; neurodegenerative diseases ; conditioned medium ; exosomes ; biomaterials Subject RIV BO - Biophysics OECD category Biophysics R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000674740100001 EID SCOPUS 85111024985 DOI 10.3389/fcell.2021.695900 Annotation Preclinical and clinical studies with various stem cells, their secretomes, and extracellular vesicles (EVs) indicate their use as a promising strategy for the treatment of various diseases and tissue defects, including neurodegenerative diseases such as spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). Autologous and allogenic mesenchymal stem cells (MSCs) are so far the best candidates for use in regenerative medicine. Here we review the effects of the implantation of MSCs (progenitors of mesodermal origin) in animal models of SCI and ALS and in clinical studies. MSCs possess multilineage differentiation potential and are easily expandable in vitro. These cells, obtained from bone marrow (BM), adipose tissue, Wharton jelly, or even other tissues, have immunomodulatory and paracrine potential, releasing a number of cytokines and factors which inhibit the proliferation of T cells, B cells, and natural killer cells and modify dendritic cell activity.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2023 Electronic address https://hdl.handle.net/11104/0333788
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