Electrochemical Techniques in Monitoring of Nervous System Drugs

0557922 - ÚFCH JH 2024 RIV CZ eng C - Conference Paper (international conference)
Choińska-Mlynarczyk, Marta - Hrdlička, Vojtěch - Skopalová, J. - Šelešovská, R. - Kolivoška, Viliam - Navrátil, Tomáš
Electrochemical Techniques in Monitoring of Nervous System Drugs.
41. Moderní elektrochemické metody. Sborník přednášek. Ústí nad Labem: Best servis, 2022 - (Navrátil, T.; Fojta, M.; Schwarzová, K.), s. 64-68. ISBN 978-80-905221-9-0.
[Moderní elektrochemické metody /41./. Jetřichovice (CZ), 22.05.2022-26.05.2022]
R&D Projects: GA ČR(CZ) GA20-01589S
Institutional support: RVO:61388955
Keywords : nervous system drugs * active pharmaceutical ingredient * metabolites * electrochemistry
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Drugs of the nervous system (ATC group N) belong generally to the most commonly (mis)used substances worldwide. Their determination and monitoring of these drugs and their metabolites in various body fluids or environmental matrices represent a challenge for analytical chemists. Our research is focused on the application of electrochemical methods in the monitoring of the most frequently prescribed and the newly introduced nervous system drugs of precisely specified structures and/or of defined properties. For toxicological and pharmacokinetic reasons, emphasis has been placed on investigating the reaction mechanisms of their metabolite formation. New or alternative to commonly used electroanalytical methods applicable for monitoring and characterization of target compounds in their pure state, in body fluids, wastewaters, and other environmental matrices, has been developed. To improve the chemometric parameters and sensing characteristics, attention was paid to the construction of new electrochemical sensors, detectors (e.g. screen-printed, 3D printed), or cells, based on (modified/unmodified) traditional or nontraditional materials, preferably usable at the point-of-care.
Permanent Link: http://hdl.handle.net/11104/0331813