Number of the records: 1  

Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells

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    SYSNO ASEP0556879
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePoly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells
    Author(s) Shapoval, Oleksandr (UMCH-V) ORCID, RID
    Engstová, Hana (FGU-C) RID, ORCID
    Jirák, D. (CZ)
    Drahokoupil, Jan (FZU-D) RID, ORCID
    Sulková, K. (CZ)
    Berková, Z. (CZ)
    Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
    Holendová, Blanka (FGU-C) RID, ORCID, SAI
    Ježek, Petr (FGU-C) RID, ORCID
    Horák, Daniel (UMCH-V) RID, ORCID
    Source TitleACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244
    Roč. 14, č. 16 (2022), s. 18233-18247
    Number of pages15 s.
    Languageeng - English
    CountryUS - United States
    Keywordsnanoparticles ; gadolinium fluoride ; luminescence
    Subject RIVCD - Macromolecular Chemistry
    OECD categoryPolymer science
    Subject RIV - cooperationInstitute of Physiology - Cell Biology
    Institute of Physics - Solid Matter Physics ; Magnetism
    R&D ProjectsGA21-04420S GA ČR - Czech Science Foundation (CSF)
    EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    GA20-07313S GA ČR - Czech Science Foundation (CSF)
    Research InfrastructureCzech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
    Method of publishingLimited access
    Institutional supportUMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 ; FZU-D - RVO:68378271
    UT WOS000812811100001
    EID SCOPUS85129046996
    DOI10.1021/acsami.2c04274
    AnnotationNovel Yb,Tb,Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid-co-maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb3+, Tb3+, and Nd3+ ions in the NaGdF4 host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). In vitro toxicity of the nanoparticles and their cellular uptake efficiency were determined in model rat pancreatic β-cells (INS-1E). As the NaGdF4:Yb,Tb,Nd@PSSMA-EG nanoparticles were non-toxic and possessed good luminescence and magnetic properties, they were applicable for in vitro optical and MRI of isolated pancreatic islets in phantoms. The superior contrast was achieved for in vivoT2*-weighted MR images of the islets transplanted under the kidney capsule to mice in preclinical trials.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2023
    Electronic addresshttps://pubs.acs.org/doi/10.1021/acsami.2c04274
Number of the records: 1  

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