Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells

Shapoval, Oleksandr; Engstová, Hana; Jirák, D.; Drahokoupil, Jan; Sulková, K.; Berková, Z.; Pop-Georgievski, Ognen; Holendová, Blanka; Ježek, Petr; Horák, Daniel

doi:https://dx.doi.org/10.1021/acsami.2c04274

Number of the records: 1

Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells

1.

SYSNO ASEP	0556879
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells
Author(s)	Shapoval, Oleksandr (UMCH-V)_{ORCID, RID} Engstová, Hana (FGU-C)_{RID, ORCID} Jirák, D. (CZ) Drahokoupil, Jan (FZU-D)_{RID, ORCID} Sulková, K. (CZ) Berková, Z. (CZ) Pop-Georgievski, Ognen (UMCH-V)_{RID, ORCID} Holendová, Blanka (FGU-C)_{RID, ORCID, SAI} Ježek, Petr (FGU-C)_{RID, ORCID} Horák, Daniel (UMCH-V)_{RID, ORCID}
Source Title	ACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244 Roč. 14, č. 16 (2022), s. 18233-18247
Number of pages	15 s.
Language	eng - English
Country	US - United States
Keywords	nanoparticles ; gadolinium fluoride ; luminescence
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Institute of Physiology - Cell Biology Institute of Physics - Solid Matter Physics ; Magnetism
R&D Projects	GA21-04420S GA ČR - Czech Science Foundation (CSF)
	EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA20-07313S GA ČR - Czech Science Foundation (CSF)
Research Infrastructure	Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 ; FZU-D - RVO:68378271
UT WOS	000812811100001
EID SCOPUS	85129046996
DOI	10.1021/acsami.2c04274
Annotation	Novel Yb,Tb,Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid-co-maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb3+, Tb3+, and Nd3+ ions in the NaGdF4 host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). In vitro toxicity of the nanoparticles and their cellular uptake efficiency were determined in model rat pancreatic β-cells (INS-1E). As the NaGdF4:Yb,Tb,Nd@PSSMA-EG nanoparticles were non-toxic and possessed good luminescence and magnetic properties, they were applicable for in vitro optical and MRI of isolated pancreatic islets in phantoms. The superior contrast was achieved for in vivoT2*-weighted MR images of the islets transplanted under the kidney capsule to mice in preclinical trials.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2023
Electronic address	https://pubs.acs.org/doi/10.1021/acsami.2c04274

Number of the records: 1