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Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
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SYSNO ASEP 0555849 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension Author(s) Šilhavý, Jan (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Šimáková, Miroslava (FGU-C) RID, ORCID
Liška, František (FGU-C) ORCID, RID
Kubovčiak, Jan (UMG-J)
Sticová, E. (CZ)
Pravenec, Michal (FGU-C) RID, ORCIDArticle number 376 Source Title Biomedicines. - : MDPI
Roč. 10, č. 2 (2022)Number of pages 16 s. Language eng - English Country CH - Switzerland Keywords salt-sensitive hypertension ; spontaneously hypertensive rat ; skin ; sodium ; salt ; blood pressure ; capillary rarefaction ; gene expression OECD category Physiology (including cytology) Method of publishing Open access Institutional support FGU-C - RVO:67985823 ; UMG-J - RVO:68378050 UT WOS 000767682600001 EID SCOPUS 85124105877 DOI 10.3390/biomedicines10020376 Annotation Recent studies in humans and rats suggested that increased Na+ storage in the skin without parallel water retention may predispose to salt-sensitive hypertension. In the current studies, we compared tissue Na+ storage in salt sensitive spontaneously hypertensive rats (SHR) versus salt resistant normotensive Brown Norway (BN-Lx) rats. After salt loading (10 days drinking 1% NaCl solution), the SHR showed significant parallel increase in Na+-to-water as well as (Na++K+)-to-water ratios suggesting increased storage of osmotically inactive Na+ in the skin while no significant changes in skin electrolyte concentrations were observed in BN-Lx rats. SHR rats after salt treatment exhibited a nonsignificant decrease in skin blood capillary number (rarefaction) while BN-Lx rats showed significantly increased skin blood capillary density. Analysis of dermal gene expression profiles in BN-Lx rats after salt treatment showed significant up-regulation of genes involved in angiogenesis and proliferation of endothelial cells contrary to the SHR. Since the skin harbors most of the body’s resistance vessels it is possible that blood capillary rarefaction may lead to increased peripheral resistance and salt sensitivity in the SHR. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://www.mdpi.com/2227-9059/10/2/376
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