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Peptidyl ketoamides as inhibitors of rhomboid proteases

SYSNO ASEP	0549178
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	Peptidyl ketoamides as inhibitors of rhomboid proteases
Author(s)	Stříšovský, Kvido (UOCHB-X)_{RID, ORCID} Majer, Pavel (UOCHB-X) Stanchev, Stancho (UOCHB-X)_{RID, ORCID} Tichá, Anežka (UOCHB-X)_{ORCID, RID}
Year of issue	2021
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	EP3638686
Date of the patent acceptance	27.10.2021
Name of the patent owner	Ústav organické chemie a biochemie AV ČR v.v.i
Code of the issuer name	EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/
Current use	A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
Language	eng - English
Keywords	rhomboid protease ; inhibitor ; ketoamide
OECD category	Biochemistry and molecular biology
R&D Projects	LK11206 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LO1302 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
Annotation	A compound of formula (I) or a pharmaceutically acceptable salt, ester or pro-drug thereof: wherein R1 is a substituent, R2 and R5 are hydrogen or alkyl, R3 and R4 are hydrogen or a substituent, or, taken together with the atoms to which they are attached, R1 and R2 or R1 and R3 form a heterocyclyl ring, R6 and R7 are hydrogen or a substituent, or, taken together with the carbon atom to which they are attached, R6 and R7 form a cycloalkyl or heterocyclyl ring, W represents (Aaa)n, wherein each Aaa is an independently selected amino acid, n is an integer of from 1 to 20. These compounds are inhibitors of rhomboid intramembrane proteases based on peptidyl ketoamides. The compounds, and pharmaceutical compositions containing them, can be used for the use in the treatment of e.g. malaria, Parkinsons disease, cancer, diabetes and bacterial infections.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2022
Electronic address	https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3638686B1&KC=B1&FT=D&ND=4&date=20211027&DB=&locale=en_EP

Number of the records: 1