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Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters
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SYSNO ASEP 0542409 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters Author(s) Vojtěchová, Iveta (FGU-C) ORCID, RID
Malenínská, Kristýna (FGU-C) ORCID, RID
Kútna, V. (CZ)
Klovrza, O. (CZ)
Tučková, K. (CZ)
Petrásek, Tomáš (FGU-C) RID, ORCID, SAI
Stuchlík, Aleš (FGU-C) RID, ORCIDArticle number 3274 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 6 (2021)Number of pages 31 s. Language eng - English Country CH - Switzerland Keywords lipopolysaccharide ; maternal immune activation ; prenatal infection ; chronic bacterial infection ; parvalbumin-positive interneurons ; macrocephaly ; schizophrenia ; autism ; sex differences ; development Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GA19-03016S GA ČR - Czech Science Foundation (CSF) NV17-30833A GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000645699300001 EID SCOPUS 85102846319 DOI 10.3390/ijms22063274 Annotation Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes, males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://www.mdpi.com/1422-0067/22/6/3274
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